There have been a series of recent publications that show that rFVIIa can traffic through the intact endothelium and be stored in the subendothelium of several organs for a prolonged period of time. Furthermore, the mechanism of action of rFVIIa and its short half life have been used as arguments against its role in prophylaxis. However, there is no general consensus on how this treatment should be put into practice, as publications have been very heterogeneous in the dosing schedule they report. Pacheco de Melo 3081 PB, 1425, Buenos Aires, Argentina Fax: (5411) 4805-0712 int: 29 e-mail: prophylaxis with rFVIIa has been the subject of several publications in the past few years. Castex, Academia Nacional de Medicina, J.A. Raúl Pérez Bianco, Instituto de Investigaciones Hematológicas Mariano R. Castex, Academia Nacional de Medicina, Buenos Aires ĢFundación de la Hemofilia, Buenos Aires, Argentina Raúl Pérez Bianco 1, 2, Daniela Neme 2, Miguel Candela 1, 2, Miguel de Tezanos Pinto 1, 2ġInstituto de Investigaciones Hematológicas Mariano R. Secondary prophylaxis with rFVIIa in hemophilia and inhibitors: Recommendations from an Experts Committee from Argentina
